Categories: Nasal Ketamine

Nasal Esketamine – SPRAVATO – for Severe Depression

Nasal Esketamine is a medicine that has been approved for the treatment of severe depression. Also known as SPRAVATO, this nasal spray is used in conjunction with an oral antidepressant. It is ideal for adults with treatment-resistant depression (TRD). If you have received treatment for depression and your symptoms have not improved, you may have TRD. Read on to find out how Nasal Esketamine can help you with TRD.

Nasal Esketamine

For most people, taking an antidepressant or going through psychotherapy eases depression symptoms. But in the case of treatment-resistant depression, standard treatments are not enough. The treatments may not help much at all. Sometimes, the symptoms may improve only for them to keep coming back. The symptoms of TRD can range from mild to severe. If a person has already tried different antidepressants and they have not worked, a health care provider may recommend SPRAVATO.

How it is used

SPRAVATO may help improve symptoms of major depression that have not improved with other approaches. It is a good option for people who have tried and not benefited from at least two antidepressant treatments. People should only use the nasal spray under supervision in the health care facility or doctor’s office. Patients also have to be monitored for a few hours every time after using the spray. A patient should discuss with a health care provider about how long to stay on it. This may be determined based on several things, including the patient’s response to it and how stable that response is.

The dosing frequency may be based on how the patient feels. A patient may have to take it two times a week for the first four weeks. During the second month, it should be taken once every week. A person may then be required to take it either once a week or once every two weeks. The oral antidepressant should continue being taken as prescribed.

Side effects

People who intend on taking it should know that it may cause side effects. Some of the side effects can be serious. The health care provider should be made aware of any symptoms that are severe or do not go away. SPRAVATO can cause a temporary increase in a patient’s blood pressure that may last for a couple of hours after taking a dose. A health care provider should check a patient’s blood pressure before taking the medicine and for about two hours after taking it.

A health care provider should be alerted right away if a person experiences worrisome symptoms. These include chest pain, sudden severe headache and shortness of breath. A patient may also find it difficult to think clearly or experience bladder problems. These should also be brought to the attention of a health care provider.

Takeaway

SPRAVATO can be used to manage a major depressive disorder. It is mostly recommended for people who have tried at least two antidepressants and they did not work. But it has to be used together with an oral antidepressant. It may cause side effects, but you should tell your health care provider if the symptoms are severe or last for a long time. If you want to find out more about Nasal Esketamine and the possible side effects, talk to your psychiatrist.

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Don A. DuBose, M.D., M.S.

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