Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
A ketamine infusion is an alternative method of drug abuse treatment. Although the drug has been used medically for more than 50 years, ketamine to treat drug and alcohol abuse is relatively new, so you may not know much about it. The following is a review of the purpose of a ketamine infusion and the…
Esketamine has been around for decades for various uses, although more recently, nasal esketamine treatment is being utilized by psychiatrists and other health professionals to treat depression. By learning more about nasal esketamine treatment, you can determine whether pursuing treatment is right for you.Studies of nasal esketamine are still ongoing, but many patients who have depression…
Spravato® is a brand-name form of nasal esketamine. Esketamine is a drug that has been used medically for decades, but Spravato® has only been approved for use in patients with depression and related conditions since March of 2019. This review aims to provide a clearer definition of Spravato® with insights into what it is effective…
Nasal esketamine treatment is a relatively new development in pharmaceutics as it related to treatment-resistant depression and drug abuse disorder. Since many patients are unfamiliar with how it works, they often feel nervous or unsure about this treatment, and understanding what to expect can help you decide whether nasal esketamine treatment is right for you.Nasal…
Looking into depression treatment options from a psychiatrist? Spravato® is a prescription medicine recently approved by the FDA. It is the first nasal spray medication for adults who have already tried taking anti-depressants and experienced no or few positive results.Considering a new depression treatment? Spravato® was recently approved by the Food and Drug Administration as…