Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
Transcranial magnetic stimulation, or TMS, is highly effective as a therapy for patients who desire relief from depression symptoms. However, certain factors may enhance efficiency and boost results when combined with TMS therapy. When it comes to treating depression, every minor effort counts to ensure complete physical health, to improve mood, to manage depression, and…
Anxiety is one of the more common mental health concerns in the United States. If you are experiencing signs of anxiety, such as worry that cannot be controlled, heart palpitations, rapid breathing, or shaking hands, it is possible that these symptoms could be diagnosed as an anxiety disorder. Patients who are evaluated by psychiatrists for…
In 2019, the Food and Drug Administration approved nasal ketamine treatment to treat depression. If you are suffering from this mental health condition, this spray could be a good alternative to other antidepressants. Your doctor can talk to you more about this treatment and its possible effects. It is important for you to understand how…
In psychiatry, doctors study and treat a wide range of conditions. Difficult life events can bring on some of these issues. Post-traumatic stress disorder is a good example. It is important for you to recognize the signs of this illness. Once you know it is affecting your life, you can get the help you need.…
If you struggle with depression, ketamine infusion therapy might be the right answer. Of all health problems, this is one of the most serious. Not only does it affect the mind but also the body. Sadly, more than 50% of people do not respond to traditional medication and treatment. Rather than be a part of…