Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
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FDA-approved nasal ketamine just may be the solution you are looking for when diagnosed with depression. If you are still suffering from depression despite having tried other treatment options, you can ask your psychiatrist for more information on this new treatment option. If your psychiatrist determines that you are a good candidate for nasal ketamine,…
Ketamine infusions are a great way to treat severe depression, suicidal thoughts, PTSD and other mental health complications. It is often effective in instances where other types of treatment such as antidepressant medication fail.It is helpful to have a complete understanding of how many and how often ketamine infusions are needed during the treatment process.The…
Nasal ketamine treatment is now available as an additional treatment option for patients who have been diagnosed with depression. The FDA recently approved the drug as a treatment for depression, which is often recommended for those who have tried other options and have so far experienced no success. Patients are given their dose by a…
Ketamine infusions are often a great way to treat more severe symptoms of depression and mood disorders. They often work when other psychiatric treatments do not.However, it is important to have a complete understanding of what they are and how they work before beginning treatment. By gaining a more in-depth understanding of ketamine infusions, you can…