Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
As an emerging way to combat depression, ketamine infusion therapy is catching the interest of mental illness patients. When other methods have not been effective, you may want to think about ketamine. Your doctor may prescribe this therapy, or you may express interest in it. It is helpful to know how this drug works and…
Ketamine infusion is quickly becoming popular as an effective treatment for anxiety, depression and post-traumatic stress disorder. Visiting the medical office for ketamine infusion might seem somewhat unnerving, especially if when not familiar with the process. Knowing what to expect during an appointment can help patients prepare better for the treatment.The patient will first meet…
Depression is real. It is a crushing problem for millions of people in the United states and across the world. It is an all-encompassing burden that many people carry, often in silence. Like many things, depression occurs on a spectrum. It can range to mild symptoms to severe enough that people cannot get out of…
Knowing about other applications of ketamine as an anesthetic and recreational drug, it is normal to be concerned about the side effects of nasal ketamine treatment. Unlike all of the general uses, ketamine for mental health disorder and pain management is administered in minimal doses. However, like any other drug, nasal ketamine treatment too, has…
Are you having a hard time overcoming or struggle with symptoms of depression? If so, you may be a good candidate for Spravato®, a nasal esketamine treatment from a psychiatrist, especially if other treatment methods have not worked thus far for your condition. During your visit for nasal esketamine treatment, the psychiatrist may discuss your current symptoms,…