Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
In the psychiatric treatment of PTSD, a blended approach involving both psychotherapy and medication is the most common course of action. Treatment for PTSD tends to be highly individualized, as what works for one patient may not work for another.Most therapists experienced with the treatment of PTSD will use one form of Cognitive Behavioral Therapy,…
Neurofeedback therapy measures the brainwaves of a patient in order to help re-train their brain and alleviate symptoms related to mental and neurological illness. Administered using sound and visuals to stimulate brain activity, neurofeedback sends signals to create desirable and positive brainwave activity. This technology has been used to help patients with a variety of…
Ketamine infusion was once primarily used as a sedative in operating rooms and on battlefields. Recently, the drug is becoming popular as an effective treatment for depression, which is a major cause of disability around the world. In the United States, estimates reveal 16 million Americans suffered from major depression during a year, which is…
If you have any type of mental health problem, then a psychiatrist can help with it. However, you may be wondering how a psychiatrist will help. There are a number of different treatment options that a psychiatrist offers. The right one will depend on your mental health condition. However, first, it is important to understand…
IV Vitamin Therapy can boost your energy, your mood, your immune system and even your metabolism and ability to lose weight. It is a more effective, faster and a more complete option than oral supplements. IV Vitamin Therapy is an innovative and effective procedure that offers immediate results. Intravenous (or IV) Vitamin Therapy delivers vitamins…