Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
Over the years, research has shown that ketamine can be used to successfully treat severe cases of depression. Despite the success doctors had using it to treat depression, the drug was not approved by the Food and Drug Administration because of the risks associated with its use.In March, the FDA finally approved the use of…
Nasal ketamine treatments provide an alternative to the more than 16 million people in the United States that are dealing with severe depression because close to a third of them have been unable to get relief from conventional antidepressants and other treatment options. If their depression is left untreated, it can lead to an increased…
These days, ketamine infusions are used to treat severe cases of depression, which is a far cry from its days of being abused by party goers. So, what made what used to be known as a party drug one of the most successful methods for treating depression?According to medical professionals, ketamine treats depression by temporarily…
In March, the Food and Drug Administration approved the use of nasal ketamine treatments to treat depression, making it the first anti-depression medication to be approved in decades. The medication also provides an alternative for patients who have become resistant to their anti-depression medication.For years, research has suggested that ketamine could be used to effectively…
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