Spravato™ Nasal KetamineColumbia, SC
Spravato, a New Approach to Treat Depression
In 2018, Ketamine was used to help rescue 12 young men and their coach who were trapped in a cave in Thailand for 16 days, The anesthetic was given to sedate and calm the young men so that the rescuers could navigate the tunnel and get each person to safety. Today we recognize Ketamine not only for aiding in this rescue, but also for it safe and proven effectiveness in treating PTSD, depression, and anxiety.
An antidepressant inhaled as a nasal spray is the first drug approved in 30 years that acts on a different chemical system in the brain than previous medications.It is aimed at patients whose depression does not respond to traditional treatment or if their condition is so overwhelming it puts them at risk of suicide.
The drug, generically called esketamine, is a product of Janssen Pharmaceutical Co. and will be sold under the brand name Spravato.
The U.S. Food and Drug Administration approved it with the caveat that it be administered under the supervision of a health care provider. Spravato can cause sedation and dissociation — feeling disconnected from one's thoughts and feelings.
The prescription drug is for patients with a form of depression known as treatment-resistant, a devastating condition that affects about a third of those diagnosed with depression, all of whom have gone from one medication to another without success.
“Approximately 33% of people with depression don’t get better with traditional antidepressants.” reports Dr. Don A. DuBose. “IV ketamine has been a life saver for many people, now we have an option to treat with Spravato and get insurance coverage. This will expand access to more people who need help!”
The medication; like IV Ketamine, acts on the most prominent signaling network in the brain: the glutamate system. Spravato blocks glutamate's action on specific sites called NMDA receptors, causing severe depression to vanish. NMDA stands for N-methyl-D-aspartate, an amino acid derivative.
Spravato is the first antidepressant to act on the glutamate system. It works as rapidly as 1 week to reduce or resolve depression symptoms.
Older antidepressants, such as Prozac, act on another key chemical system in the brain — serotonin — and can take as long as six to eight weeks to ease depression, studies have shown. Prozac and drugs like it are known as selective serotonin reuptake inhibitors, which beat back depression by increasing serotonin levels in the brain.
Looking into depression treatment options from a psychiatrist? Spravato® is a prescription medicine recently approved by the FDA. It is the first nasal spray medication for adults who have already tried taking anti-depressants and experienced no or few positive results.Considering a new depression treatment? Spravato® was recently approved by the Food and Drug Administration as…
Many health care providers recommend Nasal Esketamine spray for the management of treatment-resistant depression (TRD). This depression is resistant to other treatments. You might have TRD if you have been treated for depression but your symptoms have not improved. But you should not lose hope. There are many other approaches that your health care provider…
Nasal Esketamine spray is used in conjunction with medication taken by mouth to manage depression. It is only supposed to be used in a health care setting. This should be under the supervision of a health care provider. You will not be able to use it at home.Before taking the medicine, a person should weigh…
Nasal Esketamine can help treat patients with depression that is resistant to treatment. It is recommended for people who have tried and received no benefit from other antidepressant treatments. This nasal spray is also referred to as SPRAVATO®. Read on to find out how you should use it and what you should tell your health…
Nasal Esketamine is a medicine that has been approved for the treatment of severe depression. Also known as SPRAVATO, this nasal spray is used in conjunction with an oral antidepressant. It is ideal for adults with treatment-resistant depression (TRD). If you have received treatment for depression and your symptoms have not improved, you may have…